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American Society of Plant Biologists

Article Metrics

Parental DNA Methylation States Are Associated with Heterosis in Epigenetic Hybrids

Overview of attention for article published in Plant Physiology, December 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

blogs
1 blog
twitter
11 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
28 Dimensions

Readers on

mendeley
72 Mendeley
citeulike
1 CiteULike
Title
Parental DNA Methylation States Are Associated with Heterosis in Epigenetic Hybrids
Published in
Plant Physiology, December 2017
DOI 10.1104/pp.17.01054
Pubmed ID
Authors

Kathrin Lauss, René Wardenaar, Rurika Oka, Marieke H. A. van Hulten, Victor Guryev, Joost J. B. Keurentjes, Maike Stam, Frank Johannes

Abstract

Despite the importance and wide exploitation of heterosis in commercial crop breeding, the molecular mechanisms behind this phenomenon are not completely understood. Recent studies have implicated changes in DNA methylation and small RNAs in hybrid performance, however, it remains unclear whether epigenetic changes are a cause or consequence of heterosis. Here, we analyze a large panel of over 500 A. thaliana epigenetic hybrid plants (epiHybrids), which we derived from near-isogenic but epigenetically divergent parents. This proof-of-principle experimental system allowed us to quantify the contribution of parental methylation differences to heterosis. We measured traits such as leaf area (LA), growth rate (GR), flowering time (FT), main stem branching (MSB), rosette branching (RB) and final plant height (HT) and observed several strong positive and negative heterotic phenotypes among the epiHybrids. Using an epigenetic quantitative trait locus mapping approach, we were able to identify specific differentially methylated regions (DMRs) in the parental genomes that are associated with hybrid performance. Sequencing of methylomes, transcriptomes and genomes of selected parent-epiHybrid combinations further showed that these parental DMRs most likely mediate remodeling of methylation and transcriptional states at specific loci in the hybrids. Taken together, our data suggest that locus-specific epigenetic divergence between the parental lines can directly or indirectly trigger heterosis in Arabidopsis hybrids independent of genetic changes. These results add to a growing body of evidence that points to epigenetic factors as one of the key determinants of hybrid performance.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 72 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 15%
Researcher 10 14%
Student > Master 8 11%
Student > Bachelor 8 11%
Student > Postgraduate 4 6%
Other 14 19%
Unknown 17 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 36 50%
Biochemistry, Genetics and Molecular Biology 11 15%
Unspecified 2 3%
Decision Sciences 1 1%
Social Sciences 1 1%
Other 1 1%
Unknown 20 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2019.
All research outputs
#1,356,315
of 14,465,534 outputs
Outputs from Plant Physiology
#697
of 9,157 outputs
Outputs of similar age
#54,347
of 401,888 outputs
Outputs of similar age from Plant Physiology
#33
of 139 outputs
Altmetric has tracked 14,465,534 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,157 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 401,888 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 139 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.